Transdermal selegiline for the treatment of major depressive. Serious interactions these medications may interact and cause very harmful effects. Do not wear more than one selegiline patch at a time. Emsam selegiline transdermal system is a monoamine oxidase inhibitor. Feb 15, 2008 transdermal selegiline is an expensive treatment option for patients with major depressive disorder who have not responded to other antidepressants or who cannot swallow or take oral medications. For selegiline, the effect may result from the formation of toxic quantities of an amphetamine metabolite. No studies have been conducted to evaluate drug interactions on the pharmacokinetics of zelapar. Most of these products should never be taken with the selegiline transdermal patch.
Mao exists as two isoenzymes, referred to as maoa and maob. Your doctor may need to change your treatment plan if you have used any of the following drugs within the past 2 to 5 weeks. No drug interaction studies have been conducted to evaluate the effects of other drugs on the pharmacokinetics of zelapar or the effect of selegiline on other drugs. Interactions between transdermal selegiline and cocaine infusion.
Selegiline oral eldepryl side effects, medical uses. Selegiline has a greater affinity for maob, compared to maoa. When applied to intact skin, emsam is designed to continuously deliver selegiline over a. Emsam selegiline transdermal system may treat, side effects, dosage, drug interactions, warnings, patient labeling. In hopes of circumventing the need for dietary restrictions see drug interactions, the transdermal selegiline patch was developed to bypass the gastrointestinal tract and avoid interaction with the intestinal mucosa monoamine oxidasea maoa. Ssris and snris are among the drugs that can potentially interact with the selegiline transdermal patch. A phase 1 trial of pharmacologic interactions between. When applied to intact skin, emsam is designed to continuously deliver selegiline over a 24hour period. Some young people have thoughts about suicide when first using an antidepressant. Hypertension is predicted to occur when highdose selegiline is taken with tyraminerich foods such as mature cheese, salami, pickled herring, bovril, oxo, marmite or any similar meat or yeast extract or fermented soya bean extract, and some beers, lagers or wines. Selegiline transdermal patch emsam for major depressive.
Taking the selegiline transdermal patch with many cough, cold, and allergy products including eye drops or nasal products can increase your risk of dangerous side effects, such as high blood pressure. Place your emsam transdermal system patch on one of the following areas sites on your body. Selegiline transdermal route before using mayo clinic. Tell each of your healthcare providers about all medicines. The potential for drug interactions between emsam and a variety of drugs. Selegiline can improve your mood and feelings of wellbeing. Selegiline hydrochloride drug bnf content published by nice. This medicine is a monoamine oxidase inhibitor maoi. Emsam transdermal interactions with other medication. Many drugs can interact with selegiline, and some drugs should not be used together. Selegiline and two of its metabolites, methamphetamine and.
Selegiline base is a colorless to yellow liquid, chemically described as nmethyln1r1methyl2phenyl ethylprop2yn1amine. Selegiline skin patch may cause some people to be agitated. Appropriate studies performed to date have not demonstrated geriatricspecific problems that would limit the usefulness of selegiline skin patch in the elderly. Selegiline skin patch should not be used in children younger than 12 years of age. Concurrent use with meperidine or other opioid analgesics may possibly result in a potentially fatal reaction excitation, sweating, rigidity, and. Selegiline the drug substance of emsam is an irreversible inhibitor of monoamine oxidase mao, an intracellular enzyme associated with the outer membrane of mitochondria. Do not take selegiline if you have used meperidine eg, demerol or an mao inhibitor maoi eg, isocarboxazid, phenelzine, tranylcypromine, marplan. Moderate drug interaction using selegiline together with ethanol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Drug interactions with the selegiline transdermal patch. Selegiline should not be used at daily doses exceeding those recommended 10 mgday because of the risks associated with nonselective inhibition of mao. Serotoninsyndromeconfusion,agitation, hyperpyrexia, hypertension, seizures may occur with concurrent. Administration of these drugs with transdermal selegiline may cause.
Selegiline hydrochloride drug bnf content published by. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Emsam selegiline transdermal system side effects, images. Drug interactions with maois have been another public health concern. See what others have said about selegiline, including the effectiveness, ease of use and side effects. We would like to show you a description here but the site wont allow us. Serious drug interactions can occur when certain medicines are used together with selegiline. Our emphasis on potential drug drug interactions and contraindications should be useful to prescribers who counsel patients with mdd. There are 11 disease interactions with selegiline which include. Selegiline transdermal interactions with other medication. Selegiline oral eldepryl side effects, medical uses, and. Ibm micromedex it is very important that your doctor check your progress at regular visits to allow for changes in your dose and to check for any unwanted effects. Consumer information about the medication selegiline oral eldepryl, includes side effects, drug interactions, recommended dosages, and storage information. Whenever a drug is metabolized by multiple, simultaneous pathways, this minimizes the possibility of the drug interacting with other drugs and causing drug drug interactions.
Read more about the prescription drug selegiline oral. Drug information on emsam selegiline transdermal includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. Topics az slideshows images quizzes supplements medications. Patients should report any symptoms such as occipital headache, palpitations, neck stiffness or soreness, nausea, sweating, dilated pupils and photophobia.
You should not use an emsam patch if you have an adrenal gland tumor or if you are using certain other medicines. The sts patch is also contraindicated for patients undergoing. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. Avoiding intestinal maoa interaction decreases the risk of dietary tyramine accumulation and. This drug may rarely cause an attack of extremely high blood pressure hypertensive crisis, which may be fatal. The selectivity of selegiline for maob may not be absolute even at the recommended daily dose of 10 mg a day. In vitro studies have demonstrated that selegiline is not an inhibitor of cyp450 enzymes. Some products that may interact with selegiline include. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or. While you are wearing a selegiline patch, protect the patch from direct heat such as heating pads, electric blankets, heat lamps, saunas, hot tubs, and heated water beds. Selegiline in combination with the opioid analgesic pethidine is not recommended, as it. Itraconazole 200 mg qd did not affect the pharmacokinetics of selegiline single 10 mg oral, swallowed dose. Selegiline is metabolized by multiple cytochrome p450 enzymes, including 2c9, 2b6, 3a4, and to a minor degree by 2a6.
Find patient medical information for selegiline transdermal on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. If you have questions about the drugs you are taking, check with your doctor, nurse or. Alexander bodkin at mclean hospital, an affiliate of harvard medical school, began a collaboration with somerset to develop delivery of selegiline via a transdermal patch in order to avoid the well known dietary restrictions of mao inhibitors. Selegiline may also be used for purposes not listed in this medication guide. Transdermal delivery of selegiline at the effective dose of 6 mg every 24 hours eliminates the need for a tyraminerestricted diet. Nine published articles 23 32 met the criteria for documentation of clinical treatment combining stimulants and monoamine oxidase inhibitors. Jul 26, 2017 emsam transdermal systems are available in three strengths that deliver approximately 6 mg, 9 mg, or 12 mg of selegiline over 24 hours. Selegiline prevents the breakdown of chemicals in the brain that are often imbalanced in people with depression. Read the medication guide available from your pharmacist before you start using selegiline and each time. A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4hour cocaine infusion.
The first area that probably contributed most widely to the hesitancy of prescribing emsam by clinicians is a continued fear of an maoiinduced hypertensive crisis the tyraminebased cheese reaction, most notably seen in the 1960s prior to dietary restrictions being imposed, as well as drug drug interactions and serotonin syndrome. Emsam selegiline dose, indications, adverse effects. Combining stimulants and monoamine oxidase inhibitors. Some people may also experience impairment in thinking, judgment, and motor coordination. Drugs az pill identifier supplements symptom checker diseases dictionary media. Our emphasis on potential drugdrug interactions and contraindications should be useful to prescribers who counsel patients with mdd. Selegiline transdermal route description and brand names. Place your emsam transdermal system patch on one of the following areas sites on. Drugs that may interact with selegiline include antidepressants, stimulants, and many cold medicines. Selegiline skin patch is used to treat mental depression in adults. In these cases, your doctor may want to change the dose, or other precautions may be necessary. The inhibitor causes a decrease in the metabolism of dopamine.
Jan 22, 2020 emsam may also be used for purposes not listed in this medication guide. However, in theory, heat may result in an increase in the amount of selegiline absorbed from the patch and produce elevated serum levels of selegiline. Does selegiline patch, transdermal 24 hours interact with other medications. A case report documenting successful treatment with the combination of the selegiline transdermal patch and lisdexamfetamine is. Most of the restrictions for sts, however, are extrapolated from known experience with or theoretical concerns about drug interaction sequelae involving other maois. However, the potential for drugdrug interactions has been identified with carbamazepine. Interactions between transdermal selegiline and cocaine. On outpatient days days 5 and 9, samples were taken 5 minutes prior to application of the selegiline patch to determine steady state trough concentrations css of selegiline and metabolites. Serotoninpromoting drugs can lead to a serotonin syndrome, a state. Selegiline transdermal route precautions mayo clinic. Drug interaction precautions are recommended for the sts table 3, similar to those recommended for high dose oral selegiline and other nonselective maois. Drug interaction studies described below were conducted with emsam 6 mg24 hours. This emedtv page outlines other medicines that may cause drug interactions with selegiline and describes the negative effects of these interactions.
Use of emsam with these drugs is contraindicated see contraindications and warnings and precautions. Do not expose the patch to direct sunlight for very long. Serious, sometimes fatal, central nervous system cns toxicity referred to as the serotonin syndrome has been reported with the combination of nonselective maois and serotonergic drugs. Concurrent use with meperidine or other opioid analgesics may possibly result in a potentially fatal reaction excitation, sweating, rigidity, and hypertension. If the patch loosens or falls off before it is time to replace it, try to press it. Average aucinf nghrml of selegiline and the three major metabolites estimated for a single, 24hour application of an emsam 6 mg24 hours patch and a single, 10 mg oral immediate release dose of selegiline hcl in 12 healthy male and female. Some mixtures of medications can lead to serious and even fatal consequences. Webmd provides information about which foods to avoid while taking selegiline transdermal. This study evaluated the safety of and pharmacologic interactions between 7 days of transdermal selegiline dosed with patches selegiline transdermal system, sts that deliver 6. The potential for drug interactions between emsam and a variety of drugs was examined in several human studies. Emsam selegiline transdermal uses, side effects, dosage.
Although maob inhibitors are thought to have fewer drug interactions than maoa inhibitors, clinical data have found that when the dose is increased, typical maoa drug interactions, such as the cheese effect, may be seen. Many drug and food interactions can increase this risk see also drug interaction section. Do not apply selegiline patches to skin that is hairy, oily, irritated, broken, scarred, or calloused. There are several other interactions with the selegiline transdermal patch, many of which are serious. This emedtv web page explains how drug interactions with the selegiline transdermal patch can increase your risk of dangerous side effects. Selegiline side effects, dosage, interactions drugs. Both the oral and patch forms come with strong warnings against combining selegiline with drugs that could produce serotonin syndrome, such as ssris and the cough medicine dextromethorphan. In these cases, your doctor may want to change the dose, or other. Nov 09, 2018 serious drug interactions can occur when certain medicines are used together with selegiline. This study evaluated the safety of and pharmacologic interactions between 7 days of transdermal selegiline dosed with patches selegiline transdermal system, sts that deliver 6 mg24 hours and 2.
The sts patch is also contraindicated for patients. Selegiline can cause hypertensive reactions and it should be used with caution in patients with hypertension. Selegiline transdermal is used to treat major depressive disorder in adults and adolescents who are at least 12 years old. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions with the. Emsam selegiline transdermal system is a transdermally administered antidepressant. Stop using selegiline and get medical help right away if any of these very serious side effects occur. The selegiline transdermal patch emsam delivers higher, more sustained blood. Selegiline is an antidepressant monoamine oxidase inhibitor that treats depression by restoring the balance of certain natural substances neurotransmitters in the brain.
1172 691 1127 5 348 1188 182 1349 482 774 1254 879 75 593 165 588 636 1494 88 927 1247 1138 661 1428 1101 163 60 1022 799 532 202 960 1292